Those in the know are forecasting a gold sweep for Swiss pharmaceutical company Actelion at the upcoming 2012 Sleep Olympics. Their contender, Almorexant, has been in serious training since his discovery in 1998. He is expected to win medals from the Olympics in 1998. # 39; gold in all of the following events:
- Prescription for insomnia
- Enhancer for dreams
- Catalyst for memory
- Stimulating for creativity
- Performance accelerator
- Depressant for obesity
No country, or currently available sleeping pill, came close to winning in all categories. Most left participants lazy, depressed, restless, confused, and complaining of muscle pain during the day.
Almorexant, already in phase III testing and development, will likely win gold in the sleep competition in 2012. Testing now is to determine low doses, effects of increasing doses and effects. secondary to the sleeping pills currently in use. . Amorexant, was discovered and developed by the Swiss pharmaceutical company Actelion. Imagine the global market for a drug that will help insomnia sufferers, which will improve REM sleep and therefore improve your dream state, which will act as a catalyst to improve memory consolidation, which will stimulate your creativity by reorganizing the memory patches, which will also speed up and reduce the regulation of food in the brain and therefore reduce obesity. The drug has already shown that it can improve all of the above. Orexin, a neuropeptide produced by the hypothalamus, affects the body's sleep-wake cycle as well as the regulation of eating or appetite. The main ingredient in Almorexant acts as an orexin receptor antagonist in the brain.
The active ingredient, orexin-RA-1, when given to rats was found to stimulate deep sleep and peak performance in maze tests the next morning. They outperformed all rats given conventional sleeping pills, suggesting improved memory capacity. “Measurements of muscle tone and brain activity revealed an increase in the dream phase of sleep. The dream phase of sleep is when memory is hardwired into the brain ”. says Jean Paul Clozel, CEO of Actelion.
Shahrad Taheri, from the University of Bristol, believes that blocking the orexin system would lead to decreased appetite and therefore decreased obesity.
Studies have shown that orexin neurons in the brain are active during waking hours and they are silent during sleep. The orexin antagonist, orexin-RA-1, has been shown to be much more effective than melatonin, benzodiazepines, opiates, and histamines in penetrating the brain, increasing sleep time total, the sleep time in REM stage, the acceleration time to fall asleep, and it does. do not cause motor disturbances like other sleeping pills.
Isaac Kobrin, M.D. and former Head of Clinical Development at Actelion and now Medical Director of Actelion, found in Medicalnewstoday.com attests to the positive effects of almorexant on REM and non-REM sleep. He thinks this translates to better performance the next day than benzodiazepine drugs.
So far, no adverse effects or safety concerns have been reported in the tests that have been performed. With over 80 million Americans suffering from insomnia and 25 million or more chronic insomnia, almorexant is poised to win the expected gold medals in 2012 and to become one of the ten best drugs of the future. According to drug.com, in 2008, the most popular sleeping pill, Ambien CR, was No. 43, registering $ 865,719 in retail sales and a drop of 1.2% from 2007. The second most popular sleeping pill, Lunesta , was No. 47, recording $ 771,019 in retail sales and an 8.2% increase over 2007. Just to compare #, the No. 1 drug prescribed in 2008 was Lipitor, the cholesterol depressant, which recorded $ 5,880,128 in retail sales which was a 4.6% decrease from 2007 Ambien CR and Lunesta can both have serious side effects such as laziness, depression, memory problems, restlessness, heartbeat rapidity, confusion, decreased coordination and muscle pain, etc.
Almorexant, after being tested and approved, will become the 2012 Olympic Sleeping Champion, the Wonder Drug of Dreams, and his name will become as familiar on television as Michael Phelps. The millions of sleep deprived people around the world will finally get the 'good night's sleep' they deserve as well as the sweet dreams to improve memory, creativity and performance.